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                  1. Graduiertenkolleg 2274
                  2. Research

                  Research

                  The main goal of the research programme is to foster innovation in the field of experimental and clinical medical physics to improve the detection, characterization and treatment of cancer, thus opening new avenues in the field of image-guided cancer therapy. GRK2274's main focus is on advancing imaging and therapy with non-ionizing and ionizing radiation, from more fundamental pre-clinical developments up to clinical translation and evaluation, in close connection with experienced clinicians. In addition to the Ph.D. projects, the research programme comprises clinical projects for M.D. candidates. The twofold goal is to ensure the clinical relevance of the research projects as well as to establish a platform where physicists and other researchers can communicate with clinical partners to acquire an understanding of the specific principles and challenges of the different disciplines.

                  The research programme is structured in three core areas:

                  Research Area A - Computing
                  Computing is a research area where technologies that can benefit several applications are explored and developed, with emphasis on advanced modelling of radiation transport by Monte Carlo methods (MC) and image processing by machine learning algorithms.

                  Research Area B - Imaging
                  This area comprises research in imaging using multiple modalities, e.g. phase-contrast X-ray imaging, single photon counting for spectral CT, dual energy computed tomography (DECT), hybrid PET/MRI systems and advanced MRI sequences for functional imaging, fingerprinting and radiomics.

                  Research Area C - Therapy
                  Research area C will address fundamentally new developments in pre-clinical external radiotherapy (RT) based on laser-accelerated protons, as well as advance treatment techniques already in clinical use, namely external radiotherapy with photons and neutrons, internal radionuclide therapy and photodynamic therapy. 


                  Projects in Research Area A - Computing

                  Topic

                  Principal Investigator(s) / Co-PI(s) 

                  Doctoral Candidate(s)

                  A1 -  Hybrid patient model for MC computing 

                  K. Parodi / G. Dedes

                  E. Kollitz, M. Chen

                  A2 - Automated image segmentation for RT planning

                  B. Menze, S. Combs

                  F. Navarro

                  Projects in Research Area B - Imaging

                  Topic

                  Principal Investigator(s) / Co-PI(s) 

                  Doctoral Candidate(s)

                  B1 - Phase-contrast imaging and spectral CT in phantom studies and animal models  

                  F. Pfeiffer, J. Herzen 

                  J. Scholz, T. Sellerer

                  B2 - Phase-contrast imaging for radiotherapy

                   P. Coan

                   M. Romano

                  B3 - Dual energy CT for small animal imaging

                  J. Wilkens 

                  M. Duda

                  B4 - Dual energy CT for proton therapy

                  K. Parodi / G. Landry 

                  K. Niepel, G.Hu, H.Schmitz (associate)

                  B5 - Image reconstruction in spectral CT

                  D. Pfeiffer

                  J.Hammel, S. Beck (M.D.)

                  B6 - Image reconstruction in PET/MRI

                  S. Nekolla 

                  B. Bogdanovic, H. Porger (M.D.)

                  B7 - Robust evaluation of IVIM- and DCE-MRI for perfusion quantification

                  B. Ertl-Wagner / M. Ingrisch, O. Dietrich 

                  A. Mittermeier, S. Karkavitsas

                  B8 - Machine learning and quantitative imaging: multimodal physiological maps via MRI fingerprinting 

                  M. Menzel, B. Menze 

                  S.Endt

                  Projects in Research Area C - Therapy

                  Topic

                  Principal Investigator(s) / Co-PI(s) 

                  Doctoral Candidate(s)

                  C1 - Ionoacoustic detection of laser-driven ion beams 

                  J. Schreiber, K. Parodi 

                  S. Gerlach

                  C2 - Secondary neutrons at laser-driven proton sources 

                  W. Rühm/ V.Mares 

                  M. Tisi

                  C3 - Neutron therapy planning 

                  J. Wilkens, S. Combs 

                  L. Sommer

                  C4 - Adaptive radiotherapy physics 

                  C. Belka / G.Landry/F.Kamp

                  M. Rabe, M. Kawula (associate), Y.-C. Chan (associate), L. Huang (associate), Z. Sui (associate)

                  C5 - MC based dosimetry for radionuclide therapy 

                  S. Ziegler / G. Böning, H. Ilhan 

                  J. Brosch-Lenz, M.Rumiantcev, S. Resch, G.Liubchenko

                  C6 - Interstitial photodynamic therapy 

                  R. Sroka / A. Rühm 

                  M. Aumiller, C. Heckl (associate), M. El Fahim (M.D.), M. Foglar (M.D.)

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                  Graduiertenk...

                  • News & Events
                  • Research
                  • Publications
                    • Publications
                    • Acknowledgements
                  • Qualification
                    • Seminar and Guest Speaker
                    • Annual Retreat 
                    • Joint Summer School GRK 2274/GCB
                    • Course Medical Oncology
                    • TAC
                    • Workshop
                  • Equal Opportunities
                  • People
                  • Application
                  • Contact